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HIV Activists Seek to Accelerate Development of Immune Enhancing Therapies for Immunologic Non-Responders
Dialogues with FDA, scientists and industry encourage consideration of orphan drug designations for therapies to help the immunologic non-responder population and exploration of novel endpoints to reduce the size of efficacy trials.
November 30, 2016 – A coalition of HIV/AIDS activists are calling for renewed attention to HIV-positive people termed immunologic non-responders (INRs), who experience suboptimal immune system reconstitution despite years of viral load suppression by antiretroviral therapy. Studies have shown that INR patients remain at increased risk of illness and death compared to HIV-positive people who have better restoration of immune function on current drug therapies. Risk factors for becoming an INR include older age and a low CD4 count at the time of treatment initiation. To date, efforts to develop immune enhancing interventions for this population have proven challenging, despite some candidates from small companies showing signs of promise.

Keep the Pressure on Congress: Stop 21st Century Cures
November 30, 2016 – This Morning: Urgent Action and Calls Still Needed to Stop the 21st Century Cures Act!
Update: Since last week, your critical action to block the 21st Century Cure Act (H.R. 6) during the ongoing lame-duck session of Congress has been working. Chuck Grassley (R-IA), Elizabeth Warren (D-MA), Bernie Sanders (D-VT), and Rosa DeLauro (D-CT) have all protested, calling for stopping the bill in its tracks, until significant changes are made. More urgent action is needed with calls to legislators this morning – the Senate will be increasingly influenced by how the House votes and perceives the bill.

Action Alert: Call Congress to Stop the 21st Century Cures Act
November 21, 2016 – Treatment Action Group (TAG) is calling-on organizational partners and individual activists in the fight against HIV/AIDS to contact key members of the House of Representatives urging them not to support a new version of the 21st Century Cures Act (H.R. 6) in the lame-duck session.

Increasing Funding for TB Research: An Advocacy Strategy Webinar
On November 16, 2016, TAG held a community webinar on advocacy for TB R&D funding. This webinar builds upon TAG's annual Report on Tuberculosis Research Funding Trends to begin discussion on next steps for TB R&D funding advocacy into 2017. Panelists discussed the importance of TB research and implications of stagnant funding, shared insights into what to expect in the TB R&D pipeline, and strategized on what we can do as a community to push for change and the necessary political will under a new US presidential administration.

2016 Symposium Stop Double Standards: From Prevention through Cure to ZERO TB (VIDEO)
November 17, 2016 – On October 27, 2016, in Liverpool, UK, Treatment Action Group, Advanced Access & Delivery, Harvard Medical School, Partners In Health, and the Stop TB Partnership sponsored a symposium in conjunction with the Union World Conference on Lung Health.

Research Toward a Cure
November 15, 2016 – A listing of clinical trials and observational studies related to the research effort to cure HIV infection.

Reconsideration of support for impending 21st Century Cures Act
October 27, 2016—Dear Minority Leader Pelosi: On behalf of Treatment Action Group (TAG), I write to you strongly urging for the reconsideration of your support for the passage of the 21st Century Cures Act. Even as an impending and new version of the bill is set to be introduced by Energy and Commerce Chairman, Rep. Fred Upton – we are concerned that several provisions carried from the prior iteration of the bill (H.R. 6) may continue to undermine public health and jeopardize patient safety. These concerns include lowering standards for the FDA in determining approval for prospective drugs and devices, increasing the likelihood of antimicrobial resistance, to granting extended market exclusivity for new drugs.

2016 Report on Tuberculosis Research Funding Trends, 2005–2015: No Time To Lose
October 25, 2016 – Tuberculosis (TB) killed 1.8 million people in 2015, making it the most deadly infectious disease worldwide, but funding for research into better TB prevention, diagnosis, and treatment dropped by US$53.4 million, according to Treatment Action Group’s 2016 Report on Tuberculosis Research Funding Trends, 2005–2015: No Time to Lose. In 2015, the world spent US$620.6 million on TB research and development (R&D), the lowest level of funding since 2008. This marks the second straight year that funding for TB R&D has fallen, raising doubts over whether world leaders will fulfill recent promises to combat antimicrobial resistance (AMR) and eliminate TB by 2035.

Funding for Tuberculosis Research Falls to Lowest Level in Seven Years
Liverpool, United Kingdom, October 25, 2016—Tuberculosis (TB) killed 1.8 million people in 2015, making it the most deadly infectious disease worldwide, but funding for research into better TB prevention, diagnosis, and treatment dropped by US$53.4 million, according to a report issued today by Treatment Action Group (TAG). In 2015, the world spent US$620.6 million on TB research and development (R&D), the lowest level of funding since 2008. This marks the second straight year that funding for TB R&D has fallen, raising doubts over whether world leaders will fulfill recent promises to combat antimicrobial resistance (AMR) and eliminate TB by 2035.

Petition to BRICS countries to triple funding for TB R&D
October 17, 2016 – Tuberculosis (TB) is the world’s deadliest infectious disease, and research into new ways to prevent, diagnose, and treat TB is urgently needed. BRICS countries—Brazil, Russia, India, China, and South Africa—are home to nearly half of all the world’s new TB cases and deaths, yet only provide 4 percent of funding for R&D to prevent them. In anticipation of the 6th Meeting of the BRICS Health Ministers, please join our call for BRICS countries to triple funding for TB research and development (R&D).

Breakthrough: Catalyzing R&D to End TB
October 2016 – There is great hope for ending tuberculosis (TB)—the world’s leading infectious disease—thanks to both scientific progress and increased ambition from policymakers. But achieving this goal will require more investments in research and development (R&D). With funding trends distressingly on the decline for TB R&D, political action is critical to bend the curve up toward the development of breakthrough diagnostics, treatments, and vaccines needed to realize the promise of ending TB.

AN ACTIVIST’S GUIDE TO Tuberculosis Drugs 2016 Update
October 2016 – Tuberculosis (TB) has been curable for decades, but a rise in the number of people living with drugresistant TB (DR-TB) and TB/HIV coinfection challenges global targets of zero TB deaths, new infections, suffering, and stigma. Although TB and the people it affects have changed over the years, for the most part the drugs used against it have not. In 2012, bedaquiline, used to treat DR-TB, became the first new TB drug from a new class to be approved by the U.S. Food and Drug Administration (FDA) in over 40 years; its accelerated approval was followed in 2014 by the European Medicines Agency’s (EMA’s) conditional approval of bedaquiline and another new drug, delamanid, for the treatment of some forms of DR-TB.

TAGline Fall 2016

TAG Responds to the Release of the World Health Organization's 2016 Global Tuberculosis Report
October 13, 2016 – TB is a preventable, curable disease, and the dismal lack of progress against reversing the TB epidemic is unacceptable. Last year, the World Health Organization (WHO) reported that TB had overtaken HIV as the world's leading cause of death from an infectious disease, and this year the WHO numbers show that the TB epidemic is larger than previously estimated.

#FairDrugPricesNow
September 28, 2016 – Treatment Action Group, in conjunction with the Human Rights Campaign (HRC) and the Fair Pricing Coalition Launch #FairDrugPricesNow Campaign, a new effort to organize the LGBTQ community around common-sense solutions to drug pricing and price increasing.

Epclusa Fact Sheet
September 20, 2016 – Available in English and Spanish as PDF downloads.

Letter to Hillary Clinton on HCV Drug Prices
September 19, 2016 – Dear Secretary Clinton, As a national group of healthcare providers, advocates, and patients dedicated to preventing and treating viral hepatitis, we welcome your recent comments in Cleveland regarding the high price of pharmaceutical drugs to cure the hepatitis C virus (HCV). We are encouraged by the broad support for government action on the high price of pharmaceutical drugs, especially those for viral hepatitis, and to see this issue being directly addressed by elected officials at all levels of government. However, we are writing you today out of concern that your current healthcare platform does not specifically or adequately address the national and international viral hepatitis epidemics. We must work together to raise the profile of hepatitis B and C as urgent public health priorities.

WORLD HEPATITIS DAY 2016 – Direct-Acting (Antiviral) Generics Work: Free the cure!
July 28, 2016 – To mark the significance of World Hepatitis Day, Médecins du Monde (MdM) and Treatment Action Group (TAG) have produced a new report Dying at these prices: Generic HCV cure denied, based on crowdsourced hepatitis C data from over 40 countries available at mapCrowd.org.

2016 Pipeline Report
July 15, 2016 – HIV and TB Drugs, Diagnostics, Vaccines, Preventive Technologies, Research Toward a Cure, and Immune-Based and Gene Therapies in Development

Webinar: The stigma of HIV prevention
July 13, 2016

TAG Welcomes HCV Project Co-Directors Annette Gaudino and Bryn Gay, Salutes Outgoing HCV Project Directors for their Superb Activism
June 16, 2016

Breathing Life into Flatlined U.S. Government Funding for Tuberculosis Research: FY 2017–2020 Allocations and Recommendations
June 2016 – This policy brief provides an overview of investments made by the U.S. government and explains how increasing TB R&D funding can catalyze the development of better vaccines, diagnostics, and treatments for TB. It is built upon resource tracking and reporting done by Treatment Action Group (TAG), and it recommends areas in which investments will not only fill research gaps but also provide clarity in the vision proposed by the National Action Plan and prevent the rising threat of multidrug-resistant TB (MDR-TB).

New and Updated HCV Treatment Fact Sheets Now Online
May 31, 2016 – A new fact sheet on Zepatier, and updated fact sheets on Solvaldi, Harvoni, Viekira Pak, and Daklinza now available for download.

An Open Letter to Senator Sanders Challenging the Characterization of Meeting with HIV/AIDS Activists
May 27, 2016 – Dear Senator Sanders: We are grateful that you took time to sit with us this week to discuss a broad range of issues related to the fight against HIV/AIDS. Our group represents a larger coalition of over 70 organizations and advocates from across the country who hope to use this opportunity to push forward the national conversation, which is sorely missing, about HIV/AIDS. While we were optimistic following what we felt was a productive meeting, our optimism quickly turned to disappointment when your campaign issued a news release misrepresenting the meeting with HIV/AIDS leadership entitled “Sanders Backs California Ballot Initiative to Rein in Drug Prices at Meeting with HIV/AIDS Advocates.”

Hepatitis C: No More Treatment Rationing; Universal Access to Generic Medicines Everywhere!
April 16, 2016, Barcelona – People with hepatitis C virus (HCV) and their allies from Spain and around the world have gathered at the International Liver Congress to protest the outrageous price of life-saving HCV medicines. They are pushing for generic competition to bring down the price of HCV treatment and ensure universal access.  

TAGline Spring 2016 
NEWS ON THE FIGHT TO END HIV/AIDS, VIRAL HEPATITIS, AND TUBERCULOSIS

AIDS Advocates from Across the U.S. Call upon Presidential Candidates to Make Ending the Epidemic a Priority
March 15, 2016 – Secretary Clinton's mischaracterization of the Reagan Administration on Friday, March 11, sparked nationwide upset from HIV/AIDS advocates, service providers, people living with HIV, and loved ones of those lost to the epidemic. But it also has created an opportunity to bring HIV/AIDS to the forefront of the conversation during this campaign season.

HIV Community Letter to Hillary for America
March 14, 2016 – Dear Secretary Clinton: We write to you in the sincere hope that we can work together to transform the pain caused by your March 11th mischaracterization of the Reagans’ role in the AIDS crisis into an urgently needed public discussion of a plan to end the United States HIV epidemic by the year 2025.

TAG Welcomes Delamanid’s Inclusion in the Stop TB Partnership’s Global Drug Facility
February 24, 2016 – Treatment Action Group (TAG) congratulates the Stop TB Partnership and Otsuka Pharmaceutical for arranging for the inclusion of delamanid, an important new medicine for treating some cases of multidrug-resistant tuberculosis (MDR-TB), in the Global Drug Facility (GDF). TB is the leading infectious cause of death globally, and new medicines to treat drug-resistant strains of TB are urgently needed. TAG commends the GDF and the Stop TB Partnership for their leadership in securing access to delamanid with minimal barriers and at a single flat price for all Global Fund-eligible countries.

Pre-CROI Community HIV Cure Research Workshop 2016
February 22, 2016 – On Sunday February 21, 2016, in Boston, the AIDS Treatment Activists Coalition, AVAC, European AIDS Treatment Group, Project Inform, and TAG co-sponsored a community workshop on HIV cure research. The workshop has become an annual event that takes place immediately prior to the Conference on Retroviruses and Opportunistic Infections (CROI). Slide presentations are available at the link above, and there is coverage of workshop on the EATG at CROI 2016 Facebook page.

Treatment Action Group Hails Governor Cuomo’s Proposed Legislation Allowing Minors to Maintain Confidentiality When Obtaining HIV Treatment or Preventive Therapy
February 11, 2016Governor Cuomo continues to provide globally unprecedented leadership with New York State's plan to end AIDS as an epidemic by the year 2020,” said Treatment Action Group executive director Mark Harrington. “With today's announcement that he will submit legislation allowing minors to consent to receive antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP) to treat or prevent HIV infection, New York State moves closer to achieving an AIDS-free generation in this decade. Treatment Action Group salutes the governor's sustained leadership in these efforts and calls on state legislators to rapidly and unanimously pass this lifesaving, infection-averting legislation to end AIDS and HIV acquisition among our state's youth."

MapCrowd: An Online Data Collection Platform for Hepatitis C information
February 8, 2016 – Médecins du Monde (MdM) and Treatment Action Group (TAG) are pleased to announce the launch of mapCrowd (www.mapCrowd.org), an innovative online resource and data collection platform for gathering and sharing hepatitis C information.

WEBINAR: Countering Threats to AIDS Research at NIH: What Happened and What You Can Do
February 2, 2016

WEBINAR: HIV Prevention Advocacy in the 2016 Election Year: Priorities and Challenges
January 25, 2016

TAG’s Response to the U.S. Action Plan for Combating Multidrug-Resistant Tuberculosis
January 7, 2016 – Treatment Action Group (TAG) welcomes the release of the Obama Administration’s National Action Plan for Combating Multidrug-Resistant Tuberculosis. Strengthening the domestic and global and research efforts to address multidrug-resistant tuberculosis (MDR-TB) are critical to ending the suffering this preventable, curable disease needlessly causes. However, the targets set forth in this plan are not ambitious enough to effectively stop the spread of MDR-TB. The Administration and Congress must appropriate funding levels to ensure that the U.S. can effectively address MDR-TB.

2015 Research in Action Awards Honoree Jim Eigo's Acceptance Speech

POZ Video: 2015 Research in Action Awards

Webinar: Envisioning Comprehensive HIV Prevention Service Delivery in the U.S.
December 18, 2015

HCV Fact Sheets in English and en Español
December 14, 2015 – This set of fact sheets include information on adherence to treatment, HCV diagnostics, and currently approved treatments (Sovaldi, Olysio, Viekira Pak and Technivie, Harvoni, Daklinza, and ribavirin).

2015 TAGupdate
TAG’S PROGRESS ON THE FIGHT TO END HIV/AIDS, VIRAL HEPATITIS, AND TUBERCULOSIS
December 13, 2015 

  • Letter from Kenyon Farrow, TAG's U.S. & Global Health Policy Director
  • Message from Board President Barbara Hughes
  • Ending the Epidemic Update
  • HCV Report from the Front

HCV Global Access Webinar #2: Direct-Acting Antivirals Drastically Simplify HCV Diagnosis and Monitoring.

HCV Global Access Webinar #1: The Cost of Production for HCV Treatment.

The Fair Pricing Coalition (FPC) applauds the Wyden-Grassley US Senate bipartisan Sovaldi investigation spotlighting a greed-driven pricing strategy behind Gilead’s $1,000 per pill hepatitis C drug launch
December 3, 2015 – “This remarkable investigative report is an indictment against Gilead and the US drug pricing system which allows lifesaving drugs to be priced beyond what the market can reasonably bear,”

Webinar: Envisioning comprehensive HIV prevention service delivery in the US
Join Treatment Action Group and the HIV Prevention Justice Alliance for a webinar on Thursday, Dec. 17, 2 to 3:30 p.m. ET as we discuss the current state of the HIV prevention toolbox and an introduction to the HIV prevention continuum. Moderated by TAG's Jeremiah Johnson.

An Activist’s Guide to Regulatory Issues: Ensuring Fair Evaluation of and Access to Tuberculosis Treatment
December 2015 – This guide explains different regulatory processes and terms and offers examples of how to use a variety of regulatory mechanisms to improve access to treatment. The guide also encourages activists to advocate for effective, efficient, transparent regulatory systems.

Tuberculosis Research Funding Crisis Imperils Elimination Goal
November 30, 2015, Cape Town, South Africa – Worldwide funding for tuberculosis (TB) research fell $1.3 billion short of global targets in 2014, according to a report released today by Treatment Action Group (TAG). Total funding of US$674,036,492 in 2014 amounted to barely one-third of the US$2 billion experts estimate the world must spend on TB research and development (R&D) each year to eliminate TB. Alarmingly, funding for TB drug research fell by US$25 million compared with 2013. Overall, funding for TB R&D fell by US$12 million.

Symposium: Scale Up to Get Down to Zero TB Deaths, New Infections, and Suffering
In conjunction with the 2015 Union World Conference on Lung Health Conference
Friday, December 4, 2015
18h00 – 20h30
Southern Sun The Cullinan, Protea 1 & 2
1 Cullinan Street Cape Town Waterfront
Cape Town, South Africa 8001

TAG's Response to Sen. Cassidy Statements on AIDS Research Spending
November 19, 2015 I would like to offer comments to correct the record on statements given by Senator Bill Cassidy (R-LA) at the October 7, 2015, hearing on the National Institutes of Health fiscal year 2016 budget. Several of his comments to the committee and NIH Director Francis Collins were incorrect or misleading. If his erroneous statements about AIDS research funding at the NIH are mistaken for fact, we will set a dangerous course for current and future research being conducted at the agency and undermine the prioritization process under way at the Office of AIDS Research (OAR).

TAG Response to the Release of the World Health Organization’s 2015 Global Tuberculosis Report
October 28, 2015 – Global leaders’ half-hearted response has enabled TB to overtake AIDS as the world’s leading cause of death from an infectious disease.