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Research Toward a Cure Trials Supplemental References Page

Treatment Intensification/Early Treatment

AAHIV/RV254: Antiretroviral therapy for acute HIV infection
NCT00796263

Establish and characterize an acute HIV infection cohort in a high-risk population
NCT00796146 (related observational study)

Reference list

Kroon E, Pham PT, Sirivichayakul S, et al. Transmission dynamics among participants initiating antiretroviral therapy upon diagnosis of early acute HIV-1 infection in Thailand. AIDS. 2018 Oct 23;32(16):2373-2381. doi: 10.1097/QAD.0000000000001956. 

Chintanaphol M, Sacdalan C, Chottanapund S, et al. Brief Report: Safety and Tolerability of Inguinal Lymph Node Biopsy in Individuals With Acute HIV Infection in Thailand. J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):244-248. doi: 10.1097/QAI.0000000000001780.

D'Antoni ML, Byron MM, Chan P, et al. Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities. J Infect Dis. 2018 Sep 22;218(9):1453-1463. doi: 10.1093/infdis/jiy337.

Chan P, Patel P, Hellmuth J, et al. Distribution of Human Immunodeficiency Virus (HIV) Ribonucleic Acid in Cerebrospinal Fluid and Blood Is Linked to CD4/CD8 Ratio During Acute HIV. J Infect Dis. 2018 Aug 14;218(6):937-945. doi: 10.1093/infdis/jiy260. 

Samboju V, Philippi CL, Chan P, et al. Structural and functional brain imaging in acute HIV. Neuroimage Clin. 2018 Jul 27;20:327-335. doi: 10.1016/j.nicl.2018.07.024. eCollection 2018.

Colby DJ, Trautmann L, Pinyakorn S, et al. Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection. Nat Med. 2018 Jul;24(7):923-926. doi: 10.1038/s41591-018-0026-6. Epub 2018 Jun 11.

Teigler JE, Leyre L, Chomont N, et al. Distinct biomarker signatures in HIV acute infection associate with viral dynamics and reservoir size. JCI Insight. 2018 May 17;3(10). pii: 98420. doi: 10.1172/jci.insight.98420. [Epub ahead of print]

Crowell TA, Colby DJ, Pinyakorn S, et al. Acute Retroviral Syndrome Is Associated With High Viral Burden, CD4 Depletion, and Immune Activation in Systemic and Tissue Compartments. Clin Infect Dis. 2018 May 2;66(10):1540-1549. doi: 10.1093/cid/cix1063. 

Chan P, Hellmuth J, Colby D, et al. Safety of lumbar puncture procedure in an international research setting during acute HIV infection. J Virus Erad. 2018 Jan 1;4(1):16-20. 

Henderson GE, Peay HL, Kroon E, et al. Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment. J Med Ethics. 2018 Apr;44(4):270-276. doi: 10.1136/medethics-2017-104433. Epub 2017 Nov 10. 

Hellmuth J, Colby D, Valcour V, et al. Depression and Anxiety are Common in Acute HIV Infection and Associate with Plasma Immune Activation. AIDS Behav. 2017 Nov;21(11):3238-3246. doi: 10.1007/s10461-017-1788-4. 

Sacdalan C, Crowell T, Colby D, et al. Brief Report: Safety of Frequent Blood Sampling in Research Participants in an Acute HIV Infection Cohort in Thailand. J Acquir Immune Defic Syndr. 2017 Sep 1;76(1):98-101. doi: 10.1097/QAI.0000000000001436. 

Kroon EDMB, Phanuphak N, Shattock AJ, et al. Acute HIV infection detection and immediate treatment estimated to reduce transmission by 89% among men who have sex with men in Bangkok. J Int AIDS Soc. 2017 Jun 28;20(1):21708. doi: 10.7448/IAS.20.1.21708. 

Ananworanich J, Eller LA, Pinyakorn S, et al. Viral kinetics in untreated versus treated acute HIV infection in prospective cohort studies in Thailand. J Int AIDS Soc. 2017 Jun 26;20(1):21652. doi: 10.7448/IAS.20.1.21652. 

Kessing CF, Spudich S, Valcour V,  et al. High Number of Activated CD8+ T Cells Targeting HIV Antigens Are Present in Cerebrospinal Fluid in Acute HIV Infection. J Acquir Immune Defic Syndr. 2017 May 1;75(1):108-117. doi: 10.1097/QAI.0000000000001301. 

Takata H, Buranapraditkun S, Kessing C, et al. Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection. Sci Transl Med. 2017 Feb 15;9(377). pii: eaag1809. doi: 10.1126/scitranslmed.aag1809. 

Peluso MJ, Valcour V, Phanuphak N, et al. Immediate initiation of cART is associated with lower levels of cerebrospinal fluid YKL-40, a marker of microglial activation, in HIV-1 infection. AIDS. 2017 Jan 14;31(2):247-252. doi: 10.1097/QAD.0000000000001314. 

Colby DJ, Crowell TA, Sirivichayakul S, et al. Declining trend in transmitted drug resistance detected in a prospective cohort study of acute HIV infection in Bangkok, Thailand. J Int AIDS Soc. 2016 Oct 31;19(1):20966. doi: 10.7448/IAS.19.1.20966. 

Sereti I, Krebs SJ, Phanuphak N, et al. Persistent, Albeit Reduced, Chronic Inflammation in Persons Starting Antiretroviral Therapy in Acute HIV Infection. Clin Infect Dis. 2017 Jan 15;64(2):124-131. doi: 10.1093/cid/ciw683. Epub 2016 Oct 12. 

Crowell TA, Fletcher JL, Sereti I, et al. Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation. J Int AIDS Soc. 2016 Sep 15;19(1):21163. doi: 10.7448/IAS.19.1.21163. 

Crowell TA, Phanuphak N, Pinyakorn S, et al. Virologic failure is uncommon after treatment initiation during acute HIV infection. AIDS. 2016 Jul 31;30(12):1943-50. doi: 10.1097/QAD.0000000000001148. 

Muir R, Metcalf T, Tardif V, et al. Altered Memory Circulating T Follicular Helper-B Cell Interaction in Early Acute HIV Infection. PLoS Pathog. 2016 Jul 27;12(7):e1005777. doi: 10.1371/journal.ppat.1005777. 

Ananworanich J, Chomont N, Eller LA, et al. HIV DNA Set Point is Rapidly Established in Acute HIV Infection and Dramatically Reduced by Early ART. EBioMedicine. 2016 Sep;11:68-72. doi: 10.1016/j.ebiom.2016.07.024. Epub 2016 Jul 20. 

Deleage C, Schuetz A, Alvord WG, et al. Impact of early cART in the gut during acute HIV infection. JCI Insight. 2016 Jul 7;1(10). pii: e87065. 

de Souza MS, Pinyakorn S, Akapirat S, et al. Initiation of Antiretroviral Therapy During Acute HIV-1 Infection Leads to a High Rate of Nonreactive HIV Serology. Clin Infect Dis. 2016 Aug 15;63(4):555-61. doi: 10.1093/cid/ciw365. Epub 2016 Jun 17. 

Hellmuth J, Fletcher JL, Valcour V, et al. Neurologic signs and symptoms frequently manifest in acute HIV infection. Neurology. 2016 Jul 12;87(2):148-54. doi: 10.1212/WNL.0000000000002837. Epub 2016 Jun 10. 

Ananworanich J, Sacdalan CP, Pinyakorn S, et al. Virological and immunological characteristics of HIV-infected individuals at the earliest stage of infection. J Virus Erad. 2016;2:43-48. 

Kore I, Ananworanich J, Valcour V, et al. Neuropsychological Impairment in Acute HIV and the Effect of Immediate Antiretroviral Therapy. J Acquir Immune Defic Syndr. 2015 Dec 1;70(4):393-9. doi: 10.1097/QAI.0000000000000746. 

Valcour VG, Spudich SS, Sailasuta N, et al. Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV. PLoS One. 2015 Nov 10;10(11):e0142600. doi: 10.1371/journal.pone.0142600. 

Peluso MJ, Valcour V, Ananworanich J, et al. Absence of Cerebrospinal Fluid Signs of Neuronal Injury Before and After Immediate Antiretroviral Therapy in Acute HIV Infection. J Infect Dis. 2015 Dec 1;212(11):1759-67. doi: 10.1093/infdis/jiv296. Epub 2015 May 20. 

Phanuphak N, Teeratakulpisarn N, van Griensven F, et al. Anogenital HIV RNA in Thai men who have sex with men in Bangkok during acute HIV infection and after randomization to standard vs. intensified antiretroviral regimens. J Int AIDS Soc. 2015 May 7;18:19470. doi: 10.7448/IAS.18.1.19470. 

De Souza MS, Phanuphak N, Pinyakorn S, et al. Impact of nucleic acid testing relative to antigen/antibody combination immunoassay on the detection of acute HIV infection. AIDS. 2015 Apr 24;29(7):793-800. doi: 10.1097/QAD.0000000000000616. 

Ananworanich J, Chomont N, Fletcher JL, et al. Markers of HIV reservoir size and immune activation after treatment in acute HIV infection with and without raltegravir and maraviroc intensification. J Virus Erad. 2015;1(2):116-122. Epub 2015 Apr 1. 

Ananworanich J, Sirivichayakul S, Pinyakorn S, et al. High prevalence of transmitted drug resistance in acute HIV-infected Thai men who have sex with men. J Acquir Immune Defic Syndr. 2015 Apr 1;68(4):481-5. doi: 10.1097/QAI.0000000000000502. 

Schuetz A, Deleage C, Sereti I, et al. Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation. PLoS Pathog. 2014 Dec 11;10(12):e1004543. doi: 10.1371/journal.ppat.1004543. 

Ananworanich J, Fletcher JL, Pinyakorn S, et al. A novel acute HIV infection staging system based on 4th generation immunoassay. Retrovirology. 2013 May 29;10:56. doi: 10.1186/1742-4690-10-56. 

Sailasuta N, Ross W, Ananworanich J, et al. Change in brain magnetic resonance spectroscopy after treatment during acute HIV infection. PLoS One. 2012;7(11):e49272. doi: 10.1371/journal.pone.0049272. Epub 2012 Nov 16. 

Valcour V, Chalermchai T, Sailasuta N, et al. Central nervous system viral invasion and inflammation during acute HIV infection. J Infect Dis. 2012 Jul 15;206(2):275-82. doi: 10.1093/infdis/jis326. Epub 2012 May 2. 

Ananworanich J, Schuetz A, Vandergeeten C, et al. Impact of multi-targeted antiretroviral treatment on gut T cell depletion and HIV reservoir seeding during acute HIV infection. PLoS One. 2012;7(3):e33948. doi: 10.1371/journal.pone.0033948. Epub 2012 Mar 30. 

Observational Studies

FRESH Cohort

Reference list

Piantadosi A, Freije CA, Gosmann C et al. Metagenomic sequencing of HIV-1 in the blood and female genital tract reveals little quasispecies diversity during acute infection. J Virol. 2018 Oct 31. pii: JVI.00804-18. doi: 10.1128/JVI.00804-18. [Epub ahead of print]

Ndung'u T, Dong KL, Kwon DS, Walker BD. A FRESH approach: Combining basic science and social good. Sci Immunol. 2018 Sep 14;3(27). pii: eaau2798. doi: 10.1126/sciimmunol.aau2798. 

Dong KL, Moodley A, Kwon DS, et al. Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study. Lancet HIV. 2018 Jan;5(1):e35-e44. doi: 10.1016/S2352-3018(17)30146-7. Epub 2017 Oct 1. 

Mabuka JM, Dugast AS, Muema DM, et al. Plasma CXCL13 but Not B Cell Frequencies in Acute HIV Infection Predicts Emergence of Cross-Neutralizing Antibodies. Front Immunol. 2017 Sep 8;8:1104. doi: 10.3389/fimmu.2017.01104.

Lee GQ, Orlova-Fink N, Einkauf K, et al. Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells. J Clin Invest. 2017 Jun 30;127(7):2689-2696. doi: 10.1172/JCI93289. Epub 2017 Jun 19. 

Gosmann C, Anahtar MN, Handley SA, et al. Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Immunity. 2017 Jan 17;46(1):29-37. doi: 10.1016/j.immuni.2016.12.013. Epub 2017 Jan 10. 

Kløverpris HN, Kazer SW, Mjösberg J, et al. Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression. Immunity. 2016 Feb 16;44(2):391-405. doi: 10.1016/j.immuni.2016.01.006. Epub 2016 Feb 2. 

Byrne EH, Anahtar MN, Cohen KE, et al. Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study. Lancet Infect Dis. 2016 Apr;16(4):441-8. doi: 10.1016/S1473-3099(15)00429-6. Epub 2015 Dec 24. 

Ndhlovu ZM, Kamya P, Mewalal N, et al. Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Immunity. 2015 Sep 15;43(3):591-604. doi: 10.1016/j.immuni.2015.08.012. Epub 2015 Sep 8. 

Anahtar MN, Byrne EH, Doherty KE, et al. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract. Immunity. 2015 May 19;42(5):965-76. doi: 10.1016/j.immuni.2015.04.019.