Resistance and cross-resistance among protease inhibitors
| Resistant to: | Cross-resistance profile |
|---|---|
| SQV | 10/12 patients with L90M + 48 had complete or partial loss of sensitivity to other protease inhibitors. |
| RTV | Most or all RTV-resistant isolates are resistant to IDV and NFV. |
| IDV | Broad cross-resistance; 60% resistant to SQV; 80% resistant to 141W; 100% cross-resistant to RTV and NFV. |
| NFV | Five isolates with the D30N mutation remained sensitive to three other protease inhibitors (SQV, RTV, IDV). |