July 2015 By Polly Clayden Introduction The big news since the 2014 Pipeline Report is that there is finally a solid form of lopinavir/ritonavir (LPV/r) suitable for infants and young children. On 21 May 2015, the United States Food and…
July 2015 By Polly Clayden The most striking news since the 2014 Pipeline Report is from the START (Strategic Timing of AntiRetroviral Treatment) study.1 We now have evidence from a large, randomized, controlled trial to show that CD4 count is…
July 2015 By Simon Collins and Tim Horn INTRODUCTION As a global community of people living with HIV, our needs from the antiretroviral (ARV) pipeline have changed considerably over the last 20 years. Antiretroviral treatment (ART), particularly for people starting treatment,…
July 15, 2016 By Richard Jefferys INTRODUCTION The pursuit of a cure for HIV infection has become a central plank of the overall research portfolio, and this has been officially underpinned by the revised HIV/AIDS priorities announced by the U.S…
July 15, 2016 By Tim Horn and Richard Jefferys With the continued rollout and implementation of global, national, and regional HIV incidence targets and timelines, one thing has become abundantly clear: reducing HIV rates below endemic and epidemic levels in…
July 15, 2016 By Polly Clayden INTRODUCTION The development of new antiretroviral drugs and appropriate formulations for children continues to be far too slow. There are now 2.6 million children in need of antiretroviral treatment (ART) globally. Of those treated,…
July 15, 2016 By Tim Horn and Simon Collins INTRODUCTION The year 2016 marks 20 years since combination-based antiretroviral therapy (ART) first demonstrated durable, effective and sustained HIV control. An unprecedented period of drug discovery followed, and advances in viral…
July 15, 2016 By Polly Clayden INTRODUCTION Since the 2015 Pipeline Report global antiretroviral treatment (ART) guidelines have moved to recommending “treat all” HIV positive people. With this recommendation comes the massive task of starting and keeping everyone with HIV…
Selected updates to this chapter will be posted below prior to the 2013 edition of the Pipeline Report. Feburary 2013 Update Additional clinical trials in the Research Toward a Cure/Therapeutic Vaccines/Gene Therapies categories: Genetically Modified Peripheral Blood Stem Cell Transplant…
JULY 2012 By Polly Clayden NOTE: a postscript section at the end of this article includes periodic updates since publication in June 2012. In June 2010, the WHO and UNAIDS launched Treatment 2.0, a strategic approach to the achievement of…