Leadership Lacking in Move From 3x5 to Universal Access By Mark Harrington The past year saw a number of post mortems about the World Health Organization's "3x5" initiative to support countries in treating at least 50% of their HIV-infected populations…
By Richard Jefferys The Strategies for the Management of Antiretroviral Therapy (SMART) trial was designed to investigate whether antiretroviral therapy could be used on an as-needed basis rather than continuously. The protocol involved interrupting therapy when the CD4 count was…
TB, HIV and Viral Hepatitis By Tracy Swan Disturbing reports of overlapping TB, HIV, and viral hepatitis epidemics emerged at the 2005 International AIDS Society Conference. In the newly independent states of Eastern Europe and Central Asia, HIV incidence continues…
A Crisis for People Living With HIV/AIDS Worldwide By Javid Syed Globally, TB is the most common infection and a leading cause of death among people living with HIV. Despite being curable, TB accounts for two million deaths each year.…
By Richard Jefferys Since the late 1980s researchers have recognized that HIV isolates (viruses sampled from infected individuals) can be divided into one of two categories based on their ability to replicate in particular cells in the laboratory. Originally, a…
Squandering Public Goodwill and Scarce Research Funds to Boot -- But to What End? By Richard Jefferys Altruism Betrayed On September 23, 2004, the U.S. Food and Drug Administration's Vaccines and Related Biological Products Advisory Committee held a hearing to…
A Timeline for the Initiation of the RV144 Prime-Boost Trial By Richard Jefferys 1995-2001: U.S. Military HIV Research Program/Thai Ministry of Public Health collaboration tests various combinations of ALVAC prime/Env protein boost vaccines, eventually choosing to move ahead with the…
PHS Panel Embraces Treatment Interruption "[Single episode treatment interruption] may be offered to patients with immune reconstitution, although participation in a controlled trial would be preferred. ... The long-term safety and efficacy of this approach are not known." Source: Guidelines…
Tangle of Interests and Disclosure Omissions Cracks Authors' Case for Early, Aggressive Treatment By Mike Barr "Treatment Perfected" Parallel realities, of sorts, presented themselves last month to medical literature news junkies -- which includes a goodly share of the TAG…
Brown University Clinician Leads the Way in Providing Competent Care to Coinfected Injectors By Tracy Swan Directly Observed Peg-IFN? A majority of the estimated 4 million hepatitis C virus (HCV) infections in the United States result from injection drug use…