Like the Disease They Were Once to Cure, AIDS Cocktails Threaten to Become Chronic, Long-term Killer January 2000 How to maximize effectiveness? After an enviable academic sabbatical (which included a semester or two in France and culminated in the receipt…
From the 12th Colloquium of the Cent Gardes, Marnes-la-Coquette, France, 25-27 October January 2000 Norman Letvin (Harvard Medical School) gets the party pooper prize at this year's Paris summit: "No one has yet presented compelling evidence that the immune system…
Frankfurt HIV Clinic Cohort Study of Total Treatment Interruptions Followed by Mega-HAART Not So Unforgiving After All? Viral Load Post TTI to Mega-HAART in WT-Shifters & Non-Shifters WT-shifters Non-shifters N 26/39 (66.7%) 13/39 (33.3%) change in RNA (Wk8, mean) -…
'Start and Stop' Antiretroviral Protocols To Be Evaluated by Growing Number of Therapeutic Converts Dozen or more studies underway Interest in the virologic and immunologic effects of antiretroviral treatment interruption has been growing ever since Franco Lori first presented data…
Gladstone Immunologist Challenges Thymic Status Quo, Teasing the Research Forward 'Problem of production' In HIV infection, the role of the thymus remains both hotly disputed and poorly understood -- whether its role in leading to the clinical manifestations of disease…
HIV Antibody Breakthrough in Transgenic Mice Could Prove Boon to Vaccine Effort Formaldehyde frozen fusion Recombinant HIV envelope vaccines to date have demonstrated the ability to elicit neutralizing antibodies to HIV strains from which they were constructed (as well as…
As Treatment Euphoria Ebbs, Stubborn Uncertainties Resurface But Are Unlikely to Be Resolved 'Unacceptable collective evasion' Paul Joseph Corser 1961-1999 Rod Sorge 1969-1999 With the prolonged demise of HIV eradication hypotheses and the growing appreciation of the various unpleasant realities…
Thymic Rebound, Naïve CD4+ T-Cell Repopulation Demonstrated in Individuals on HAART Vive le thymus! Even the most cutting edge immunology postdoc would have had his or her hands full preparing lesson plans from this month's "Frontiers of Immunology" piece, exhaustively…
AZT Monotherapy Veteran Checks out Chemotherapeutic Quitsville and Lives to Tell About It Don't try this at home In a recent highly unscientific and egregiously self-selective poll of HAART-experienced individuals (N=15) in New York City (most of them aging activists),…
AIDSVax Field Trial Makes a Splash While Humble Canarypox Phase II Plods Along Uncelebrated AIDS 'end game' While precious little has changed on the HIV vaccine front since last summer, when California-based VaxGen received the go-ahead to proceed with a…