2003 Pipeline Report
By Rob Camp The pipeline is bursting, with at least the following compounds twinkling in the eyes of scientists around the globe. It is by no means a full list, but those substances in red were presented at the recent…
Postition Paper on FDA Approval of Atazanavir (Reyataz)
June 2003 By Rob Camp To lipid it or not to lipid it From the Introduction Atazanavir (ATV) is an azapeptide protease inhibitor under development by Bristol- Myers Squibb, licensed from Novartis. Overall, the drug looks virologically similar to nelfinavir…
Brand New, You’re Retro
TAG Basic Science Project 2003 Retrovirus Conference Report By Richard Jeffreys May 2003 Nabbing the V3 Loop One major theme that emerged at this year's Retrovirus conference was a renaissance of interest in neutralizing antibodies. Antibodies are small Y-shaped molecules…
TAG: Position Paper on FTC (emtricitabine) brand name Emtriva®
2003 by Rob Camp INTRODUCTION FTC is a once-daily (QD) thiacytidine nucleoside analogue developed by Triangle Pharmaceuticals, North Carolina. Triangle is now owned by Gilead Sciences. The compound was licensed from Emory University in 1996. It comes in 200 mg…
Fuzeon Brand Enfuvirtide (T-20): Breaking Barriers or Breaking the Bank?
By Matt Sharp and Rob Camp for the Treatment Action Group (TAG) and Other Endorsing Community Organizations and Individuals (List Below) March 7, 2003 Introduction Research and advocacy have brought forth 16 approved antiviral medications targeting two different stages in…
Basic Science Review
By Richard Jeffreys January/February 2003 IL-2 & CD4 T Cells: Number & Function Disconnect? Therapeutic Dendritic Cell Vaccine Lowers SIV Load Protease Inhibitors and Atherosclerosis Immune Activation & Immune Deficiency: Making the Connection New Insights Into HIV Latency Viral Adaptation…
Critical Issues From TAG’s Forthcoming HCV/HIV Coinfection Report, Version 2.0
Research and Policy Recommendations for HCV/HIV Coinfection By Tracy Swan February 2003 Introduction The unfolding epidemic of hepatitis C virus (HCV) infection is a serious and growing problem. An estimated 170 million people around the world are infected. In the…
Swiss-Spanish Intermittent Treatment Trial Downer
by Richard Jeffreys January 29, 2003 When an investigational drug causes a 0.4 log drop in viral load, it is evidence of biological activity. When the first large auto-vaccination study produces the same result, it signals the end of an…