July 2018 by Tim Horn The past 12 months has been historic in terms of the number of new HIV treatment modalities reaching pharmacy shelves, at least in the United States. Four originator products – the first dual-drug regimen for…
July 2018 by Jeremiah Johnson Since 2011, HIV prevention has undergone a true revolution. With three major studies (HPTN 052, PARTNER, and Opposites Attract) now showing zero new infections linked to an HIV positive person who has successfully suppressed their…
July 2018 by Richard Jefferys The most important news in preventive HIV vaccine research over the past year is the opening of a Phase IIb trial testing the efficacy of a prime-boost approach developed by Janssen Vaccines & Prevention B.V.,…
July 2018 by Lindsay McKenna Existing tests and those under development that are designed to detect tuberculosis (TB) bacteria (see the Tuberculosis Diagnosis Pipeline, coming soon) are suboptimal for children, who often have fewer TB bacteria in their bodies than…
July 2018 by Lindsay McKenna Tuberculosis (TB) prevention research is advancing (see The Tuberculosis Prevention Pipeline), yet the inclusion of children in these studies to ensure they benefit from such advances is inconsistent. Promisingly, studies to evaluate the use of…
July 2018 by Lindsay McKenna Pharmacokinetic (PK) and safety studies in children continue to progress, producing a steady flow of data (Table 2). Yet the translation of research and development gains into policy and access for children with tuberculosis (TB)…
July 2017 By Marcus Low Editor's note: This version has been modified from the original print version on August 7, 2017 to reflect recent updates and clarify the status of access to delamanid. INTRODUCTION Arguably, the most critical questions in…
July 2017 By Annette Gaudino INTRODUCTION The continued development of direct-acting antivirals (DAAs) against hepatitis C virus (HCV) has brought both multigenotypic and pangenotypic regimens to market, with more on the horizon. These simpler-to- prescribe regimens potentially eliminate the need…
July 2017 By Lindsay McKenna INTRODUCTION An unacceptable disparity exists between the estimated burden of tuberculosis (TB) in children and the number actually diagnosed and put on TB treatment each year. In 2015, just 384,300 of an estimated one million…
