This report marks the midway point of the 1/4/6×24 Campaign, which calls for the universal implementation of the best available TB regimens — as little as one month or once weekly for TB prevention, four months for drug-susceptible TB, and six months for drug-resistant TB — by the end of 2024. The report takes stock of what 1/4/6×24 has accomplished so far since its founding in 2022, and analyzes remaining gaps to be filled to reach its ambitious goal by the end of this year — particularly pertaining to the “4” regimen, for which uptake has been sorely limited and which original modeling shows has the potential to reduce total treatment time by 6.3 million years through 2030.

The report also recognizes countries who have shown extraordinary leadership in implementing the 1/4/6 regimens, highlighting various models of delivery that have proven effective in resource-limited settings. Finally, it concludes with specific action steps that should be taken by governments, funders, industry, and global health actors to secure the best and most effective TB regimens for everyone, everywhere.