Paxlovid can reduce the risk of hospitalization or death by 89% when taken shortly after testing positive for COVID-19. This factsheet developed by IMPAACT4C19 and Treatment Action Group lays out all that you need to know about Paxlovid: what it is, who should use it, how to take it, and how it interacts with other drugs.

This guide can help inform treatment decisions during the ongoing COVID-19 pandemic, particularly for people living with HIV, TB and HCV, and is the first publication in a three-part series on Test-and-Treat interventions for COVID-19. Forthcoming publications in the series include a factsheet on a drug called molnupiravir and a guide on rapid testing and self-testing.